The opener at St. Mary’s was a sizzler. It was 90° something at KO and the Saints stormed back in the second half to earn a point.
| Date | Match | Location |
| 7/30/2022 | Southampton (1) vs Villarreal CF (2) | St. Mary’s |
| 8/13/2022 | Southampton (2) vs Leeds (2) | St. Mary’s |
| 8/23/2022 | Cambridge United (0) vs Southampton (3) | Abbey Stadium |
| 8/28/2022 | Sunderland (0) vs Norwich (1) | Stadium of Lights |
| 9/3/2022 | Norwich (3) vs Coventry (0) | Carrow Road |
| 9/10/2022 | Coventry vs West Bromwich Albion | CBS Arena |
| 9/17/2022 | Exeter City Football Club (0) versus Burton Albion (2) | St James Park |